Get Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), PDF

By Taotao Zou

This thesis specializes in the advance of gold- and non-classical platinum-based anti-cancer brokers that show distinctively diverse anti-cancer mechanisms in comparison to the widely used cisplatin. those steel complexes include N-heterocyclic carbene (NHC) ligands that are capable of shape robust M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. distinctive chemical synthesis, in vitro and/or in vivo anti-cancer actions are basically provided together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that concurrently act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) complicated with a combined diphosphine and bis(NHC) ligand showing favorable balance and exhibiting major inhibition of tumor development in self sufficient mice versions without observable unintended effects; and (iii) a panel of solid luminescent cyclometalated platinum(II) complexes showing excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER pressure and mobilephone apoptosis. those works spotlight the scientific capability that gold and platinum complexes provide for melanoma treatment.

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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses) by Taotao Zou


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